Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
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Xeloda tablets 500 mg №120 are a cytostatic agent. The active component of this drug is capecitabine, a derivative of fluoropyrimidine carbamate. This substance interacts in the tissues of tumors with thymidine phosphorylase, resulting in a cytotoxic effect, and - selective. Thus, the use of Xeloda makes it possible to achieve the necessary clinical response with minimal effect on healthy tissues. At the same time, some analogs of Xeloda, also cytostatics, have a cytostatic effect not selectively, using a tumor and healthy tissue.
This drug is used in the treatment of breast cancer, including, and in the presence of metastases, as part of complex therapy - in cases when chemotherapy was not effective. In addition, Xeloda is prescribed for the treatment of colon cancer, stomach cancer and esophagus, as well as colorectal cancer.
This medicine is not prescribed concomitantly with sorivudine and its analogs, as well as patients with renal insufficiency and/or individual sensitivity to capecitabine. It is also not recommended to use the drug for pregnant and lactating women.
Xeloda tablets are taken orally. It is necessary to take the pill no later than 30 minutes after eating. The duration of therapy and the scheme of taking Xeloda is determined by the doctor.
When using the drug Xeloda most often (in 10% of cases) noted the development of stomatitis, stool, vomiting, increased drowsiness, asthenia, fatigue and palmar-plantar syndrome.
In addition, it is possible to develop such side effects:
Disorders of appetite, pain in the epigastric and abdominal region, dry mouth mucosa, oral candidiasis, flatulence, colitis, duodenitis, gastritis, esophagitis, gastrointestinal bleeding, dermatitis, erythema, dry skin, alopecia, skin itching, skin and nail pigmentation disorders , Onycholysis, photosensitivity reactions, skin cracks. It is also possible the development of a syndrome similar to radiation dermatitis.
Common side effects: fever, asthenia, pain in the extremities, weight change, back pain, dehydration, myalgia, arthralgia, sleep disorders, paresthesia, headache, peripheral neuropathy, dizziness, encephalopathy, confusion, cerebellar symptoms, depression , Conjunctivitis, taste disorders, lacrimation, dyspnea, sore throat, epistaxis, cough, edema, angina pectoris, myocardial infarction, arrhythmia, heart failure, tachycardia, myocardiopathy, atrial fibrillation, ventricular extrasystoles, sudden death, anemia, pancytopenia, neutropenia .