Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.
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Tetracycline - an antibiotic. It has a bacteriostatic effect by suppressing the synthesis of protein pathogens. It is indicated for infectious and inflammatory diseases caused by microorganisms sensitive to tetracycline, including Pneumonia, bronchitis, pleural empyema, angina, cholecystitis, pyelonephritis, intestinal infections, endocarditis, endometritis, prostatitis, syphilis, gonorrhea, brucellosis, rickettsiosis, purulent infections of soft tissues, osteomyelia; Trachoma, conjunctivitis, blepharitis; Eels.
It is used for prevention of postoperative infections.
Tetracycline is prescribed to adults - 250-500 mg every 6 hours. Children older than 8 years - 25-50 mg per 1 kg of body weight every 6 hours.
The maximum daily dosage for adults in case of an oral administration is 4 g.
In case of prolonged use, it is necessary to monitor the functions of the kidneys, liver, and hematopoiesis periodically.
The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.
Tetracycline should not be taken concomitantly with milk and other dairy products. At the same time, absorption of the antibiotic is impaired.
•children under 8 years,
•hypersensitivity to tetracycline.
It penetrates through the placental barrier and may cause long-term discoloration of the teeth, hypoplasia of the enamel, suppression of the growth of the bones of the fetal skeleton. In addition, tetracycline may be the cause of the development of fatty liver infiltration.
On the part of digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dry mouth, glossitis, discoloration of the tongue, esophagitis, transient increase in hepatic transaminase activity, alkaline phosphatase, bilirubin concentration, residual nitrogen.
On the part of the central nervous system: dizziness, headache.
On the part of the hematopoiesis system: neutropenia, thrombocytopenia, hemolytic anemia.
On the part of allergic reactions: skin rash, itching, eosinophilia, Quincke's edema.
On the part dermatological reactions: photosensitization.
Effects due to chemotherapeutic action: candidal stomatitis, vulvovaginal candidiasis, intestinal dysbiosis.
On the part of local reactions: soreness in the injection site.
Other effects: hypovitaminosis of vitamins of group B / A.